Brain Angiotensin-II-derived Reactive Oxygen Species: Implications for High Blood Pressure
نویسندگان
چکیده
Ang II is the major effector of the Renin–Angiotensin–Aldosterone System (RAAS). This system consists mainly of a 2-step enzymatic cascade catalyzed by renin and Angiotensin-Converting Enzyme (ACE), generating Ang II [1], the effect of Ang II is mediated by Ang II receptors. Two isoforms of Ang II receptor have been identified: type 1 receptor (AT1R) and type 2 receptor (AT2R). In general, it is accepted that cardiovascular effects of Ang II such as vasoconstriction, regulation of fluid and drinking behavior are ascribed to AT1R. Besides, AT1R is involved in the progression of cardiovascular diseases including hypertension, atherosclerosis, cardiac hypertrophy and heart failure [2,3].
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